Finally it is gently pulled out the plug line after 2 h. Then the entrance of the middle cerebral artery is blocked and internal carotid artery is ligated (the blank group only exposed the left blood vessel without Plugging wire. A thread Line bolt is inserted with more than 18–20 mm from bifurcation of CCA into the internal carotid artery until there is resistance.
Besides, cut the incision of 0.2Â mm from 5Â cm of the bifurcation of the common carotid artery. Then internal carotid artery with arterial clamp is temporarily clipped. The common carotid artery and the external carotid artery are ligated.
After 1 h at 7 d to medicine, left incision in the middle of the neck of rats after anesthesia, we can firstly expose and isolate the left common carotid artery (CCA, and then expose external carotid artery (ECA and internal carotid artery (ICA. The model group, nimodipine group, cerebral collateral group, and large, medium and small dose group of the Rabdosia rubescens total flavonoids were administered with corresponding drugs but sham operation group and model group were administered the same volume of 0.5%CMC, 1 times a day, continuous administration of 7 d. Objective To study the ent-kaurane diterpenoids from Rabdosia rubescens.Methods The compounds were isolated by chromatographies and their structures were identified by spectral analyses.Results Four compounds were isolated,and they were identified as bisrubescensin E (1),2α,3α,24-trihydroxyurs-12-en-28-oic acid (2),2α,3α,24-trihydroxyurs-12,20-(30)-dien-28-oic acid (3),and 6,7-dihydroxycoumarin (4).Conclusion Compound 1 is a new asymmetric ent-kauranoid dimer.Compound 2 is isolated from the plant for the first time.Compounds 3 and 4 are isolated from the plants of Rabdosia (B1.) Hassk for the first time.Įffects of the Rabdosia rubescens total flavonoids on focal cerebral ischemia reperfusion model in ratsĭirectory of Open Access Journals (Sweden)įull Text Available The effect of the Rabdosia rubescens total flavonoids on focal cerebral ischemia reperfusion model in rats was observed. Institute of Scientific and Technical Information of China (English) On the basis of make the best use of everything, to promote the innovation and development of Chinese medicine and services to the people in our country.Ī New Asymmetric ent-Kauranoid Dimer from Rabdosia rubescens This paper inquires relevant literature, the application of Rabdosia rubescens in prescription, Chinese patent medicine and food therapy was reviewed, in order to make Rabdosiae rubescens play a greater role in the relevant area. The application of prescriptions, Chinese patent drug and food therapy of Rabdosia rubescens are less and fragmented. The clinical application of Rabdosia rubescens is restricted in the fat-soluble components, and the solubility of water solubility is ignored. It is used in the treatment of sore throat, rheumatoid arthritis and various kinds of cancer. Modern research has proved that Rabdosia rubescens has the effect of heat-clearing and detoxicating, antibacterial and anticancer, promoting blood circulation to arrest pain and anti-tumor. Rabdosia rubescens contais many active ingredients such as terpenoids, flavonoids, polysaccharides and organic acids. Study on the Application of Chinese Patent Drug and Chinese Formula of Rabdosia Rubescens
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